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fentanyl, cyproheptadine. Either raises toxicity on the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of fentanyl with anticholinergics may well increase risk for urinary retention and/or critical constipation, which can bring on paralytic ileus.If coadministration of CYP3A4 inhibitors with fentanyl is necessa